From the California Highway Patrol:

On August 30, 2016, at approximately 7:32 PM, a 1994 Ford Escort driven by a female, whose name is currently being withheld pending notification of next of kin, was traveling southbound on US-101, south of the Empire Camp rest area.  For reasons still under investigation, the Ford traveled off the west roadway edge. The Ford then re-entered the roadway and traveled across all lanes before it collided with a large tree east of US-101. Northbound US-101 traffic was restricted to one lane for the collision investigation and vehicle removal until approximately 10:44 PM. The driver, and only occupant of the vehicle, sustained fatal injuries and was pronounced deceased at the scene.

Agencies on scene were Cal-Fire, Leggett Fire, Mendocino County Sheriff, and CHP.

This collision remains under active investigation by the California Highway Patrol and it is unknown at this time if drug and/or alcohol impairment were a factor in this collision.